Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

BH2 binding can lead to eNOS uncoupling

p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 + q-BH2 → p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 + BH4

Reactome: R-HSA-1497796
Compartment: cytosol
Rhea: None recorded

Inputs

p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4R-HSA-1497830, plasma membrane
q-BH2CHEBI:43029, C9H13N5O3, cytosol

Outputs

p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2R-HSA-1497889, plasma membrane
BH4CHEBI:59560, C9H15N5O3, cytosol

Catalysed by

tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]

Literature

The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study Biochem J, 2002