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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

p-S1177-eNOS:CaM:HSP90:p-AKT1 + BH4 → p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4

Reactome: R-HSA-1497784
Compartment: cytosol · plasma membrane
Rhea: None recorded

Inputs

p-S1177-eNOS:CaM:HSP90:p-AKT1R-HSA-202121, plasma membrane
BH4CHEBI:59560, C9H15N5O3, cytosol

Outputs

p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4R-HSA-1497830, plasma membrane

Catalysed by

tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

Inputs

Outputs

Catalysed by

Literature