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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PTHP is reduced to BH4 by sepiapterin reductase (SPR)

PTHP + 2 NADPH → BH4 + 2 NADP+

Reactome: R-HSA-1475414
Compartment: cytosol
Rhea: None recorded

Inputs

PTHPCHEBI:17804, C9H11N5O3, cytosol
2 NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

BH4CHEBI:59560, C9H15N5O3, cytosol
2 NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

sepiapterin reductase (NADP+) activity of p-SPR dimer [cytosol]EC 1.1.1.153

Literature

Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis Biochem Biophys Res Commun, 1991