DHNTP is dephosphorylated by PTPS to PTHP

DHNTP → PTHP + PPP

Reactome

R-HSA-1474184

Compartment

cytosol

Rhea

None recorded

Catalysed by

• 6-pyruvoyltetrahydropterin synthase activity of p-PTPS hexamer [cytosol]EC 4.2.3.12

Literature

1. Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver Eur J Biochem, 1986
2. 6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding J Mol Biol, 1995
3. Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity Eur J Biochem, 1994
4. Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis EMBO J, 1994
5. Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II J Biol Chem, 1999