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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GCHFR binds to GCH1 and negatively regulates its activity

GCH1 decamer + 2 GCHFR pentamer → 2GCHFR:GCH1

Reactome: R-HSA-1474158
Compartment: cytosol
Rhea: None recorded

Inputs

GCH1 decamerR-HSA-1474144, cytosol
2 GCHFR pentamerR-HSA-1474155, cytosol

Outputs

2GCHFR:GCH1R-HSA-1474149, cytosol

Catalysed by

enzyme inhibitor activity of GCHFR pentamer [cytosol]

Literature

A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions J Neurochem, 2006
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity Science, 1993
GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes J Invest Dermatol, 2006