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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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GCH1 reduces GTP to dihydroneopterin triphosphate

GTP + H2O → DHNTP + HCOOH

Reactome
R-HSA-1474146
Compartment
cytosol
Rhea
RHEA:17474

Inputs

Outputs

Catalysed by

  • GTP cyclohydrolase I activity of GCH1 decamer [cytosol]EC 3.5.4.16

Literature

  1. Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme Biochem J, 1994
  2. Atomic structure of GTP cyclohydrolase I Structure, 1995